Fluorescence-based Techniques to Study the Structure and Dynamics of Mass-selected Biomolecular Ions

Laser-induced fluorescence studies on mass-selected biomolecules are a promising route to understand their properties in the gas phase and probe intrinsic solvent-free environment. Fluorescence has been used investigate conformation dynamics of gaseous biomolecular ions. With Förster Resonance Energy Transfer (FRET), it is now possible obtain sensitive intramolecular distance information from large biomolecules, like proteins, with high chemical specificity. growing interest applications, gas-phase measurements can shed greater light characteristics proteins phase. Compared solution measurements, also help influence solvent interactions protein structure function.